The Federation served as a catalyst for improving child immunization, helping create a community immunization registry implemented by the Cuyahoga County Board of Health to help ensure that all children in Cuyahoga County received preventive health care.

The Federation formed the Cuyahoga County Welfare Reform Council in response to the passage of federal and state welfare-reform legislation. The Council mobilized more than 1,000 health and social service professionals, volunteers, advocates and concerned citizens to urge legislators to support policies that help families in need.